Study of the state of the vaginal microbiota in women with risk and threat of preterm birth

The objective: to compare the state of vaginal microbiota in women with risk preterm birth and threat birth.Materials methods. study involved 150 pregnant women. inclusion criteria for were presence factors – I group (80 women) or II (70 women). control consisted 20 conditionally healthy Ultrasound (transvaginal) examination assessment carried out at 17-21+6 weeks gestation during hospitalization a confirmed pregnancy interruption 22-35+6 group. exclusion criterion was premature rupture membranes by Actium Prom test. Observation studied cohort continued until end pregnancy.To assess microbiota, determination pH content, molecular biological, bacterioscopic methods used.Results. Bacterial vaginosis mixed vaginitis diagnosed patients significantly more often than group, and, accordingly, there much smaller rate 1st degree cleanliness among .The frequency detection anaerobic dysbiosis highest (34.3 %) compared (21.3 %). Aerobic (aerobic vaginitis) only (11.4 In dysbiotic inflammatory changes vagina, is high OR=2.962 (95% CI: 1.32–6.645), while it OR=8.120 2.149 –30.686), an existing OR=10.133 3.149–32.604). Candida non.albicans mainly found recurrent episodes vulvovaginal candidiasis before pregnancy.Conclusions. Anaerobic one spontaneous threatening births, which requires development diagnostic therapeutic measures prevent termination pregnancy.